As this study does not involve any treatment interventions, there should be no specific risk to participants. The taking of blood samples (for standard laboratory tests or "biobanking") or skin biopsy (for "biobanking") causes no serious problems for most people, but it can cause some bleeding, bruising and/or discomfort at the injection site and may (in the case of the skin biopsy) leave a small scar. See the question "What is 'biobanking'?" below or the section on biobanking for more information.
The MRI/MRS scans that will be performed are commonly performed and generally safe. However, you need to be aware of the possible side effects. Some people are claustrophobic in the scanner; however, you will not be completely enclosed. The radio waves used in the MRI can cause metal and other tissues to heat up. You will therefore need to inform us if you have any of the following: surgical clips, a pacemaker or heart defibrillator, stents in the heart or arteries, an inner ear implant, a medicine infusion pump (e.g. insulin pump), a neurostimulator, a shunt in the brain, joint replacements, large metal implants, metal fragments anywhere in your body, eye, penis or breast implants, an intrauterine contraceptive device, or any body piercings. You may find that teeth fillings tingle during the scanning, but they are safe. It is also important for us to know if you have any allergies, tattoos, transdermal patches, or gun/shrapnel wounds.