Exon Skipping

Think of a mutated dysferlin gene as an electrical wire that has a fault somewhere in the middle. The idea behind exon skipping is to remove the fault by cutting the wire on either side of the fault and then rejoining the two ends of the wire so that the fault is removed. The resulting wire is shorter than the original one, but can potentially still do the same job. A mutated dysferlin gene can also be thought of as a scratched CD. When you get to the damaged section of the CD, the music cannot proceed, but exon skipping is like skipping past the track where the scratched section is, so you can listen to the rest of the album.