Structure and Function of the Domains of Human Dysferlin
Dysferlin is a large protein with several tandem protein domains of unknown structure and function. However, mutations in these domains have been linked to LGMD. The identifiable domains include seven C2 domains, a FerA domain, and DysF. This project examined the structure and function of the C2 domains as well as the internal domains of dysferlin, FerA and DysF.