Preventing Dysferlinopathy Through Anti-Cholesterol Approaches

Pascal-Nicolas Bernatchez, PhD

University of British Columbia

Pascal-Nicolas Bernatchez, PhD is an Associate Professor in the Department of Anesthesiology, Pharmacology & Therapeutics at the University of British Columbia.

Past Projects

Objective: 
To evaluate how lipids associated with 'Western' diets can participate in pathogenesis of dysferlinopathy.

Our laboratory is interested in how lipids associated to ‘Western’ diets, such as triglycerides and cholesterol, can participate to the pathogenesis of dysferlinopathy.  Using various genetic models of altered lipid metabolism in combination with dysferlinopathic mice, we are currently studying how muscle fibers respond to changes in circulating lipid and lipoproteins levels, and whether correcting certain plasma lipid parameters would attenuate the rate of decline in muscle function associated with dysferlinopathies.