Lipids in Dysferlinopathies
Objective:
To humanize rodent models of LGMD2b
Recent publications from our team have shown that notoriously mild models of muscular dystrophy can show profound exacerbation when their lipid metabolism is altered by apolipoprotein E gene activation. However, apolipoprotein E is known to modulate adipocyte and lipoprotein metabolism along with whole-body energy storage. The current project explores new avenues to humanize disease severity in dysferlin-deficient mice without interfering with normal apolipoprotein E expression.