What do the Ferlin proteins do?
It appears that in general Ferlins are involved in vesicle fusion events. When cell membranes fuse together there is an energy barrier to the fusion process, and various factors, including Ferlins and other proteins such as Synaptotagmins, are implicated in facilitating the fusion process. For example, membrane fusion is involved in the repair of muscle sarcolemma , and critically requires Dysferlin. Also, Otoferlin has been shown to interact with SNAREs and functions in synaptic exocytosis in cochlear hair cells