A Dog Model of Dysferlin Deficiency

Diane Shelton, DVM, PhD

University of California, San Diego (San Diego, CA)

Dr. Shelton is Professor in the Department of Pathology, School of Medicine, University of California, San Diego. She is also Director of the Comparative Neuromuscular Laboratory established at UCSD in 1990.

Past Projects

Objective: 
Identify a Canine Model of Dysferlin Deficient Muscular Dystrophy

The Comparative Neuromuscular Laboratory (CNL), established in 1990 at the University of California San Diego (http://vetneuromuscular.ucsd.edu), is a one of a kind international reference center for the pathologic diagnosis of spontaneous neuromuscular diseases in companion animals. The specific aim of this study is to identify a canine or feline model of dysferlin deficient muscular dystrophy by screening archived and newly received fresh frozen muscle biopsy specimens utilizing established immunoblotting and immunofluorescence methods. Once a specific breed or family of dogs is identified with dysferlin deficient muscular dystrophy, we will help other investigators establish such colonies of dogs for further investigations and testing new therapies.