Objective: To identify blood-based biomarkers that may be associated with differences in muscle function.
Project Summary: The study will compare blood samples from individuals with LGMD2B/MM with samples from healthy, age and gender-matched controls. Differences in proteins and nucleic acids in the blood that reflect differences in muscle function will be tested and validated as possible biomarkers. These biomarkers will then be used to help track disease progression and the efficacy of potential treatments in future clinical trials.
About MRM Proteomics: MRM Proteomics Inc. is a leader in providing advanced mass spectrometry based quantitative proteomics services and reagents to the pharmaceutical, biotechnology and diagnostics industries in key areas such as biomarker discovery/validation and clinical diagnostics development. For additional information, please go to www.mrmproteomics.com.
About PROOF Centre: The Centre of Excellence for the Prevention of Organ Failure (PROOF Centre) develops blood tests to diagnose, treat and manage heart, lung and kidney disease. The PROOF Centre is a cross-disciplinary engine of partners representing academia, health care, government, industry, patients and the public, to improve heart, lung and kidney health and reduce the enormous socioeconomic burden of organ disease. The centre’s service arm provides expertise in computation, “-omic” science and biomarker workflow to organizations seeking to discover, develop and implement blood-based molecular biomarkers in a clinical setting. The PROOF Centre is a not-for-profit society initially established from the Networks of Centres of Excellence Secretariat under the Centre of Excellence for Commercialization and Research (NCE CECR) Program, and is co-hosted by the University of British Columbia and Providence Health Care in Vancouver, British Columbia, Canada. For additional information, please go to www.proofcentre.ca.