Structure and Function of the Domains of Human Dysferlin

R. Bryan Sutton, PhD

Texas Tech University Health Sciences Center (Lubbock, TX)

Dr. Sutton is an Associate Professor in the department of Cell Physiology and Molecular Biophysics, at the Texas Tech University Health Science Center in Lubbock, Texas.

Past Projects

Objective: 
To study the structure of dysferlin.

Dysferlin is a large protein with several tandem protein domains of unknown structure and function.  However, mutations in these domains have been linked to LGMD.  The identifiable domains include seven C2 domains, a FerA domain, and DysF.  This project examined the structure and function of the C2 domains as well as the internal domains of dysferlin, FerA and DysF.