Mouse Models: B6.Cg-Tg(Ckm-DYSF)3Cam/J
The Jackson Laboratory
Stock number: 014146
Strain information: http://jaxmice.jax.org/strain/014146.html
Phone: 800-422-MICE (800-422-6423)
610 Main Street, Bar Harbor, Maine 04609 USA
Expression of human DYSF (dysferlin) cDNA is driven by the mouse Ckm (creatine kinase, muscle; MCK) promoter in this transgenic strain. Hemizygotes are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. Expression of dysferlin in skeletal muscle is approximately 4-8 fold that of the endogenous protein level. There is no detectable muscle pathology up to one year of age.
The human DYSF (dysferlin) cDNA with SV40 polyA was inserted downstream of the mouse Ckm (creatine kinase, muscle; MCK) promoter. The transgenic vector was introduced to B6SJLF1 hybrid embryos to create the mutation. This strain was backcrossed to C57BL/6 for six generations by the donating laboratory.
No phenotype has been published.
Campbell K. 2011. Direct Data Submission to Jackson Laboratories 2010/12/22_y4VaX3 MGI Direct Data Submission :. [MGI Ref ID J:177029]