Mouse Models: Chr6-A/J

C57BL/6J-Chr6A/J/NaJ mice

Availability:
The Jackson Laboratory
Stock number: 004384
Strain information: http://jaxmice.jax.org/strain/004384.html
Phone: 800-422-MICE (800-422-6423)
610 Main Street, Bar Harbor, Maine 04609 USA

Development:
A chromosome substitution or consomic strain with one of its chromosomes replaced by the homologous chromosome of another inbred strain. The C57BL/6J and A/J strains in this set were chosen because they differ in their susceptibility to diseases such as arthritis, asthma, atherosclerosis, cancer, several infectious diseases, inflammatory responses, and physiological, behavioral and sensory phenotypes. This particular strain has chr 6 from the A/J line with an ETn retrotransposon (5-6kb) inserted in intron 4 of the dysferlin gene, while the remaining chromosomes are from C57BL/6J.

Mutation:
An ETn retrotransposon (5-6kb) is inserted in intron 4 of the dysferlin gene.

Symptoms:
Very similar to A/J.

Control strain(s):
C57BL/6J

References:
Nadeau JH; Singer JB; Matin A; Lander ES. 2000. Analysing complex genetic traits with chromosome substitution strains. Nat Genet 24(3):221-5.