Session 1: Lipid accumulation and Fat replacement in vitro and in vivo
7:00 AM – 9:00 AM PDT (1400—1600 UTC) Tuesday, June 29, 2020
7:00 Jain Foundation–Session Introduction
7:10 Matthew Watt—University of Melbourne, Dysferlin Deficiency Alters Lipid Metabolism and Remodels the Skeletal Muscle Lipidome in Mice
7:35 Alastair Khodabukus/Nenad Bursac—Duke University, A novel 3D tissue-engineered human iPSC model of dysferlin-deficient skeletal muscle – studies of contractile function and lipid response
7:50 Anil Agarwal–UT Southwestern, Insights into Lipid Accumulation in Skeletal Muscle
8:05 Pierre Carlier—Institute of Myology, Quantitative NMR Imaging Biomarkers for Disease Progression and Disease Activity in Skeletal Muscle of Dysferlinopathy Patients: Fat Fraction and Water T2
8:20 Questions and Discussion
Tuesday, June 30, 2020: Pathways: FAPs, Cholesterol, and Metabolism
7:00 Jain Foundation–Session Introduction
7:10 Jyoti Jaiswal–George Washington University and Children’s Research Institute, Misdirected Fate of a Multipotent Stem Cell Drives Disease Progress in LGMD2B
7:35 Lorenzo Puri–Sanford Burnham Prebys Medical Discovery Institute, Investigation of the Role of Fibro/Adipogenic Progenitors and the Effect of HDAC Inhibitors in Dysferlinopathy
7:50 Pascal Bernatchez—University of British Columbia, Is Muscle Wasting in Dysferlinopathies the Result of Whole-Body Lipoprotein Abnormalities? Lessons from Duchenne Muscular Dystrophy
8:15 Questions and Discussion
